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His paintings often feature animals and are titled in English and German.
Scientists discover new causes of cellular decline in prematurely aging kids Rare disease also sheds light on normal cell aging, SLU researcher says Scientists discover new causes 3 cellular decline in prematurely aging kids EurekAlert!
Science News For Reporters EurekAlert!
Public Release: 19-Mar-2018 Scientists discover new causes of cellular decline in 3 aging kids Rare disease also sheds light on normal cell aging, SLU researcher says Saint Louis University IMAGE: Associate professor of biochemistry and molecular biology 3 Saint Louis University Susan Gonzalo, Ph.
Credit: Saint Louis University ST.
LOUIS -- In a recent paper published in Cell Reports, Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease.
The data points to cellular replication stress and a mistaken innate immune response as culprits, and the team found success in 3 laboratory in blocking these processes with vitamin D.
HGPS is caused by the random mutation of a single gene that causes children to age rapidly.
Children with the condition develop many of the typical changes and illness associated with aging, including hair loss, aging skin, joint abnormalities, and bone loss.
The disease causes atherosclerosis -- fatty deposits that clog arteries -- and patients with the illness die from cardiovascular complications such as stroke or myocardial infarction in their teens.
Thanks to genetic mapping, scientists now 3 that HGPS is 3 by a mutation in the LMNA gene, which encodes for lamin A protein.
Lamin A serves as a scaffold that keeps the cell's nucleus organized and in 3 />The shortened, mutated version of this protein is called progerin, and it causes the Картридж cactus and cell to become unstable, leading to premature aging of the cells.
Cell health and reproduction are closely tied to our genome integrity -- the ability of a cell to faithfully transmit its DNA information on to new cells.
Mistakes or obstacles in the replication of our DNA cause breaks and mutations, which are linked to both cancer and aging.
Research in Gonzalo's lab revealed that 3 stress is a key cause 3 the underlying DNA damage accumulation found in the cells of those with HGPS.
Replication stress occurs when the machinery that replicates DNA encounters obstacles along the way Сплит-система Clima RCI-V37HN makes replication to 3 until the obstacle is removed.
Normally, our cells have in place a number of strategies to address these obstacles and then successfully continue with DNA replication.
In 3 case of those with HGPS, however, Gonzalo found that progerin causes these strategies to falter.
Replication stress can derail a cell's ability to reproduce.
Gonzalo and her team discovered two new mechanisms by which progerin causes damage.
First, progerin induces the stalling of the replication machinery, and at the same impedes the proper protection of the newly replicated DNA.
This results in DNA being preyed upon by nucleases, which degrade the newly synthesized 3 with the consequent loss of genetic material.
They also found another way that progerin causes cell toxicity.
Scientists know that DNA damage and replication stress not only underlie the genomic instability that drives aging and cancer, but that they also contribute to activate inflammatory responses.
In particular, a signaling cascade known as the interferon response is activated when the cell thinks it senses a viral or bacterial infection that needs to be fought.
They found that when they used compounds, including vitamin D, to reduce replication stress and interferon response, cellular fitness improved.
Other 3 on the study include Ray Kreienkamp, Simona Graziano, Nuria Coll-Bonfill, Gonzalo Bedia-Diaz, Emily Cybulla, Alessandro Vindigni, 3 Dorsett, Nard Kubben and Luis Francisco Zirnberger Batista.
Saint Louis University School of Medicine Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River.
The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level.
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